GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7714584 | 1 | rs11955172 | chr5:150254378 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.23 | 1.22E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11957134 | chr5:150230950 | LOC134466 | chr5:150310000-150326146:- | -0.51 | -6.73 | 6.15E-11 | Crohn's disease |
| BLCA | cis | rs853679 | 1 | rs11965538 | chr6:28239915 | ZNF389 | chr6:28129551-28137375:+ | -0.34 | -4.32 | 1.98E-5 | Depression |
| BLCA | cis | rs11976180 | 1 | rs11975942 | chr7:143740580 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.99 | 4.75E-9 | Obesity-related traits |
| BLCA | cis | rs11976020 | 1 | rs11976020 | chr7:72247800 | TYW1B | chr7:72023729-72298813:- | 0.99 | 15.64 | 5.37E-43 | Educational attainment (years of education) |
| BLCA | cis | rs11976180 | 1 | rs11976037 | chr7:143741024 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.04 | 3.73E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs11976180 | chr7:143741580 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.04 | 3.63E-9 | Obesity-related traits |
| BLCA | cis | rs1077514 | 1 | rs1198433 | chr1:23756695 | ASAP3 | chr1:23755056-23811057:- | 0.28 | 3.86 | 0.000131 | Cholesterol, total |
| BLCA | cis | rs1077514 | 1 | rs1198433 | chr1:23756695 | TCEA3 | chr1:23707555-23751261:- | 0.29 | 4.01 | 7.33E-5 | Cholesterol, total |
| BLCA | cis | rs1077514 | 1 | rs1198440 | chr1:23780861 | ASAP3 | chr1:23755056-23811057:- | 0.3 | 4.17 | 3.83E-5 | Cholesterol, total |
| BLCA | cis | rs1077514 | 1 | rs1198440 | chr1:23780861 | TCEA3 | chr1:23707555-23751261:- | 0.33 | 4.58 | 6.39E-6 | Cholesterol, total |
| BLCA | cis | rs2275426 | 1 | rs12021587 | chr1:46472759 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs6684514 | 1 | rs12022194 | chr1:156312331 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 3.88 | 0.000122 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BLCA | cis | rs17030613 | 1 | rs12030612 | chr1:113215637 | ST7L | chr1:113066142-113162405:- | 0.41 | 5.91 | 7.39E-9 | Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs17030613 | 1 | rs12030641 | chr1:113215717 | ST7L | chr1:113066142-113162405:- | 0.41 | 5.91 | 7.39E-9 | Diastolic blood pressure;Blood pressure |